Wnt Signaling in Development and Disease

Author: Stefan P. Hoppler
Publisher: John Wiley & Sons
ISBN: 9781118444153
Release Date: 2014-02-28
Genre: Science

Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions reviews the core topics in Wnt signaling, from molecular pathway mechanisms to its role in embryogenesis, adult tissue homeostasis, and chronic disease. Written by a team of expert reviewers, the book provides clear and concise coverage of the core foundations of Wnt signaling before advancing to discussion of cutting-edge scientific research. Focused on the biological insights and current scientific questions of Wnt signaling, this book will be a comprehensive and definitive resource for a wide range of researchers and students in cell signaling, cell physiology, developmental biology, and biomedical engineering, as well as anyone interested in learning more about this important and complex protein network. • A definitive source of information on Wnt signaling and its role in development and disease, written by leaders in the field. • Explores the role of Wnt signaling in chronic disease such as melanoma, colorectal cancer, dementia, and psychiatric diseases • Reviews the complex processes of signal integration and regulation • Features broad discussion of Wnt signaling biology as well as detailed discussion of the pathway’s role in diseases and potential clinical applications.

Protein Kinases in Development and Disease

Author:
Publisher: Academic Press
ISBN: 9780128016244
Release Date: 2017-02-22
Genre: Science

Protein Kinases in Development and Disease discusses and reviews important, but often neglected, kinases. A good representation of current model organisms from plants and C. elegans to mice are used as the basis to illustrate how we can use our understanding of normal development to learn about disease. Reviews kinases, the fundamental regulators of most biological processes that have key roles in the development of all organisms Includes a broad scope of topics that are addressed Allows researchers and newcomers to this research area to gain a thorough picture of the current knowledge

Cell Polarity in Development and Disease

Author: Douglas W Houston
Publisher: Academic Press
ISBN: 9780128125915
Release Date: 2017-11-14
Genre: Science

Cell Polarity in Development and Disease offers insights into the basic molecular mechanisms of common diseases that arise as a result of a loss of ordered organization and intrinsic polarity. Included are diseases affecting highly polarized epithelial tissues in the lung and kidney, as well as loss and gain of cell polarity in the onset and progression of cancer. This book provides a basic resource for understanding the biology of polarity, offering a starting point for those thinking of targeting cell polarity for translational medical research. Provides basic science understanding of cell polarity disease and development Covers diseases affecting polarized epithelial tissues in the lung and kidney, also covering the progression of cancer Includes historical context of cell polarity research for potential future breakthroughs

Cell Migration in Development and Disease

Author: Doris Wedlich
Publisher: John Wiley & Sons
ISBN: 9783527604074
Release Date: 2006-03-06
Genre: Science

Cell Migration matches nearly all research areas in cell and developmental biology, genetics, and biomedicine. The field shows radical progress powered by the combination of new genomic tools, cell labeling techniques and the incorporation of new model systems. This is the first book to comprehensively cover cell migration from the identification of molecular mechanisms to the understanding of certain pathological disorders and cancer development.

Kidney Development Disease Repair and Regeneration

Author: Melissa Helen Little
Publisher: Academic Press
ISBN: 9780128004388
Release Date: 2015-08-06
Genre: Medical

Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally Explains the underlying developmental mechanisms which influence the kidney’s inherent repair capacity Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine

Molecular Nutrition and Diabetes

Author: Didac Mauricio
Publisher: Academic Press
ISBN: 9780128017616
Release Date: 2015-12-08
Genre: Medical

Molecular Nutrition and Diabetes: A Volume in the Molecular Nutrition Series focuses on diabetes as a nutritional problem and its important metabolic consequences. Fuel metabolism and dietary supply all influence the outcome of diabetes, but understanding the pathogenesis of the diabetic process is a prelude to better nutritional control. Part One of the book provides general coverage of nutrition and diabetes in terms of dietary patterns, insulin resistance, and the glucose-insulin axis, while Part Two presents the molecular biology of diabetes and focuses on areas such as oxidative stress, mitochondrial function, insulin resistance, high-fat diets, nutriceuticals, and lipid accumulation. Final sections explore the genetic machinery behind diabetes and diabetic metabolism, including signaling pathways, gene expression, genome-wide association studies, and specific gene expression. While the main focus of each chapter is the basic and clinical research on diabetes as a nutritional problem, all chapters also end with a translational section on the implications for the nutritional control of diabetes. Offers updated information and a perspective on important future developments to different professionals involved in the basic and clinical research on all major nutritional aspects of diabetes mellitus Explores how nutritional factors are involved in the pathogenesis of both type1 and type2 diabetes and their complications Investigates the molecular and genetic bases of diabetes and diabetic metabolism through the lens of a rapidly evolving field of molecular nutrition

Cancer Signaling

Author: Christoph Wagener
Publisher: John Wiley & Sons
ISBN: 9783527800452
Release Date: 2016-08-12
Genre: Science

Cancer, which has become the second-most prevalent health issue globally, is essentially a malfunction of cell signaling. Understanding how the intricate signaling networks of cells and tissues allow cancer to thrive - and how they can be turned into potent weapons against it - is the key to managing cancer in the clinic and improving the outcome of cancer therapies. In their ground-breaking textbook, the authors provide a compelling story of how cancer works on the molecular level, and how targeted therapies using kinase inhibitors and other modulators of signaling pathways can contain and eventually cure it. The first part of the book gives an introduction into the cell and molecular biology of cancer, focusing on the key mechanisms of cancer formation. The second part of the book introduces the main signaling transduction mechanisms responsible for carcinogenesis and compares their function in healthy versus cancer cells. In contrast to the complexity of its topic, the text is easy to read. 32 specially prepared teaching videos on key concepts and pathways in cancer signaling are available online for users of the print edition and have been integrated into the text in the enhanced e-book edition.

Molecular Mechanisms of Angiogenesis

Author: Jean-Jacques Feige
Publisher: Springer
ISBN: 9782817804668
Release Date: 2014-05-27
Genre: Science

Angiogenesis is a multi-stage process that drives the generation of new blood and lymphatic vessels from pre-existing ones. It is highly active during embryogenesis, largely inactive during adulthood but reactivated during wound healing and under a number of pathological conditions including cancer and ocular diseases. In addition to endothelial cells, which line the walls of the vessels, several other cell types (pericytes, macrophages, progenitor cells...) also contribute to angiogenesis. A number of signaling pathways are activated and very finely tune the delicate morphogenetic events that ultimately lead to the formation of stable blood proof neovessels. This book reviews recent advances in our understanding of the molecular and cellular mechanisms of angiogenesis, with a focus on how to integrate these observations into the context of developmental, post-natal and pathological neovascularization. The book was published under the auspices of the French Angiogenesis Society. Most contributors are prominent members of this Society or international researchers who have actively contributed to the Annual Meetings of the Society.

Wnt Signaling in Embryonic Development

Author: Sergei Sokol
Publisher: Elsevier
ISBN: 008047134X
Release Date: 2011-09-22
Genre: Science

A superb compilation of reviews from leading experts in the field of Wnt signaling (signaling molecules that regulate cell-to-cell interactions during embryogenesis), volume 17 in the Advances in Developmental Biology series offers 7 chapters, each devoted to a separate area of research on Wnt signaling. Written by specialists in the field, these chapters cover different levels of signaling, including: ligands, receptors, cytoplasmic and nuclear components of the pathway. This book discusses a number of model systems including mice, Drosophila, Xenopus, zebrafish, C. elegans, and mammalian cells. Together, these chapters review the available knowledge and will fill gaps in our understanding of this interesting network of cell signaling processes. * Includes two parts devoted to the canonical (beta-catenin dependent) and non-canonical branches of Wnt signalling to the cytoskeleton * Offers insight to large genomic data that are now available for the analysis of Wnt gene targets * Discusses regulators of the cytoskeleton such as small GTPAses of the Rho family, jun-N-terminal kinases and other MAP kinases, and proteins involved in the generation of cell polarity

Principles of Developmental Genetics

Author: Sally A. Moody
Publisher: Academic Press
ISBN: 9780124059238
Release Date: 2014-09-02
Genre: Science

Providing expert coverage of all major events in early embryogenesis and the organogenesis of specific systems, and supplemented with representative clinical syndromes, Principles of Developmental Genetics, Second Edition discusses the processes of normal development in embryonic and prenatal animals, including humans. The new edition of this classic work supports clinical researchers developing future therapies with its all-new coverage of systems biology, stem cell biology, new technologies, and clinical disorders. A crystal-clear layout, exceptional full-color design, and bulleted summaries of major takeaways and clinical pathways assist comprehension and readability of the highly complex content. All-new coverage of systems biology and stem cell biology in context of evolving technologies places the work squarely on the modern sciences Chapters are complemented with a bulleted summary for easy digestion of the major points, with a clinical summary for therapeutic application Clinical highlights provides a bridge between basic developmental biology and clinical sciences in embryonic and prenatal syndromes

Adherens Junctions from Molecular Mechanisms to Tissue Development and Disease

Author: Tony J C Harris
Publisher: Springer Science & Business Media
ISBN: 9789400741867
Release Date: 2012-06-07
Genre: Medical

Cell–cell adhesion is fundamental for the development and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the best understood cell-cell adhesion complexes. In this volume, a group of internationally recognized experts reviews AJ biology over a wide range of organization; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and overall animal development. AJs have also been an integral part of animal evolution, and play central roles in cancer development, pathogen infection and other diseases. This book addresses major questions encompassing AJ biology. • How did AJs evolve? • How do cadherins and catenins interact to assemble AJs and mediate adhesion? • How do AJs interface with other cellular machinery to couple adhesion with the whole cell? • How do AJs affect cell behaviour and multicellular development? • How can abnormal AJ activity lead to disease?

Natural Killer Cells

Author: Michael T. Lotze
Publisher: Academic Press
ISBN: 0080919294
Release Date: 2009-11-12
Genre: Medical

Natural Killer Cells explains the importance of killer cells and how they are produced. It mentions that the most likely explanation for killer cell production is that they serve as a complementary system for T cells as a primary defense against viruses. However, these cells defend against certain viruses only, such as herpes viruses and influenza viruses. The book also explains the primary functions of killer cells, and it discusses how these cells help recognize damaged tissues, limit further damage to tissues, and regenerate damaged tissues. It discusses how these cells mature and develop, and it covers the different isolation, culture, and propagation methods of these cells. Furthermore, it focuses on the different killer cells that are present in various parts of the human body. The book concludes by explaining that natural killer cells are utilized for clinical therapy of malignancies, and that they have led to positive outcomes in the field of biology and medicine. Provides a broad, detailed coverage of the biology and interactions of NK cells for students, fellows, scientists, and practitioners Includes figures, histologic sections, and illustrations of the ontogeny of NK cells

Heart Development and Regeneration

Author: Nadia Rosenthal
Publisher: Academic Press
ISBN: 9780123813336
Release Date: 2010-05-28
Genre: Science

The development of the cardiovascular system is a rapidly advancing area in biomedical research, now coupled with the burgeoning field of cardiac regenerative medicine. A lucid understanding of these fields is paramount to reducing human cardiovascular diseases of both fetal and adult origin. Significant progress can now be made through a comprehensive investigation of embryonic development and its genetic control circuitry. Heart Development and Regeneration, written by experts in the field, provides essential information on topics ranging from the evolution and lineage origins of the developing cardiovascular system to cardiac regenerative medicine. A reference for clinicians, medical researchers, students, and teachers, this publication offers broad coverage of the most recent advances. Volume One discusses heart evolution, contributing cell lineages; model systems; cardiac growth; morphology and asymmetry; heart patterning; epicardial, vascular, and lymphatic development; and congenital heart diseases. Volume Two includes chapters on transcription factors and transcriptional control circuits in cardiac development and disease; epigenetic modifiers including microRNAs, genome-wide mutagenesis, imaging, and proteomics approaches; and the theory and practice of stem cells and cardiac regeneration. Authored by world experts in heart development and disease New research on epigenetic modifiers in cardiac development Comprehensive coverage of stem cells and prospects for cardiac regeneration Up-to-date research on transcriptional and proteomic circuits in cardiac disease Full-color, detailed illustrations

Physiology of the Gastrointestinal Tract

Author: Hamid M. Said
Publisher: Academic Press
ISBN: 9780128124260
Release Date: 2018-03-08
Genre: Medical

Physiology of the Gastrointestinal Tract, Sixth Edition, a Two-Volume set, covers the study of the mechanical, physical and biochemical functions of the GI Tract by linking clinical disease and disorder, thus bridging the gap between clinical and laboratory medicine while also covering breakthroughs in gastroenterology, such as the brain-gut axis and microbiome. Additionally, information is provided at the organism level, including animal models of gastrointestinal disorders and therapeutic possibilities. The book covers a wide range of conditions, from food allergies, constipation, chronic liver disease and IBS, also exploring emerging techniques to diagnose and normalize functions of the GI tract. As a highly referenced book, this is a useful resource for gastroenterologists, physiologists, internists, professional researchers and instructors teaching courses for clinical and research students. Discusses the multiple processes governing gastrointestinal function Presents new information on the brain-gut axis and microbiome Edited by preeminent scientists in the field Includes coverage of issues, such as food allergies, constipation, chronic liver disease, IBS, Crohn's disease, and more

Signal Transduction

Author: Bastien D. Gomperts
Publisher: Gulf Professional Publishing
ISBN: 0122896327
Release Date: 2003
Genre: Medical

Signal Transduction now in paperback, is a text reference on cellular signalling processes. Starting with the basics, it explains how cells respond to external cues (hormones, cytokines, neurotransmitters, adhesion molecules, extracellular matrix, etc), and shows how these inputs are integrated and co-ordinated. The first half of the book provides the conceptual framework, explaining the formation and action of second messengers, particulary cyclic nucleotides and calcium, and the mediation of signal pathways by GTP-binding proteins. The remaining chapters deal with the formation of complex signalling cascades employed by cytokines and adhesion molecules, starting at the membrane and ending in the nucleus, there to regulate gene transcription. In this context, growth is an important potential outcome and this has relevance to the cellular transformations that underlie cancer. The book ends with a description at the molecular level of how signalling proteins interact with their environment and with each other through their structural domains. Each main topic is introduced with a historical essay, detailing the sources key observations and experiments that set the scence for recent and current work. * Coherent, precise text providing insight in depth to a subject that is central to cell biology and fundamental to many areas of biomedicine * Conceptual colour artwork assists with the comprehension of key topics * Extensive referencing provides an invaluable link to the core and historical literature * Margin notes highlighting milestones in the evolution of our understanding of signalling mechanisms