Author: Dolph L. Hatfield
Publisher: Springer Science & Business Media
Release Date: 2012-12-06
As discussed in this book, a large body of evidence indicates that selenium is a cancer chemopreventive agent. Further evidence points to a role of this element in reducing viral expression, in preventing heart disease, and other cardiovascular and muscle disorders, and in delaying the progression of AIDS in HIV infected patients. Selenium may also have a role in mammalian development, in male fertility, in immune function and in slowing the aging process. The mechanism by which selenium exerts its beneficial effects on health may be through selenium-containing proteins. Selenium is incorporated into protein as the amino acid selenocysteine. Selenocysteine utilizes a specific tRNA, a specific elongation factor, a specific set of signals, and the codeword, UGA, for its cotranslational insertion into protein. It is indeed the 21st naturally occurring amino acid to be incorporated into protein and marks the first and only expansion of the genetic code since the code was deciphered in the mid 1960s.
Author: Dolph L. Hatfield
Release Date: 2016-09-15
In the current edition, Selenium: Its Molecular Biology and Role in Human Health expands extensively on the previous editions providing readers with the most significant advances in the rapidly developing selenium field. Evidence from epidemiology and veterinary science supports the essential role of selenium in (human) health, but its split personality in both preventing and supporting cancer and also in promoting insulin resistance has become more clearly defined. The pivotal role of glutathione peroxidase 4 in a new process of programmed cell death, ferroptosis, brings new impetus to the field. Recently defined mutations in selenoprotein and biosynthesis factor genes have been identified in patients, and the resulting disorders further emphasize the significance of selenoproteins in human health. The mechanism of selenoprotein biosynthesis, the functions of selenoproteins, and the roles of dietary selenium have been further elucidated, and new regulatory mechanisms involving selenoproteins discovered. The book, therefore, covers the breadth of current selenium research. With up-to-date chapters written by leaders in their fields, it serves as an invaluable resource for novices as well as specialists.
Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology is intended to bring to light the most recent advances in these overlapping disciplines with a timely compilation of reviews comprising each volume.
Author: Raymond F. Burk
Publisher: Springer Science & Business Media
Release Date: 2012-12-06
Selenium plays a fascinating and still poorly understood role in the function of living cells and therefore in human health. Starting with investigations over 60 years ago into its role as a toxic agent in livestock disease, selenium studies have progressed rapidly with the application of tools from immunology and molecular biology. Selenium is now known to be important in human and animal nutrition, has been discovered as a structural component of so-called selenoproteins, and may play a number of physiological roles, ranging from cancer protection to hormone metabolism. Selenium in Biology and Human Health presents research syntheses on a range of topics involving selenium, written by specialists from around the world. It will be of interest to cell biologists and physiologists, nutritional scientists, and animal health researchers.
Research over the years has demonstrated that free radicals mediated oxidative stress lies at the helm of almost all patho-physiological phenomena. These findings emphasize on the need to understand the underlying molecular mechanism(s) and their critical role in the pathogenesis. This book aims to focus on these areas to provide readers a comprehensive outlook about the major redox sensitive pathways and networks involved in various disease conditions. In the first chapter of the book, basic information about the oxidative stress, its generation, its biomarkers and its role in body are discussed. In the next three chapters, the role of oxidative stress in various pathologies ranging from neurological disorders, to cardiovascular diseases, cancers, metabolic diseases and ageing have been described. Chapter 5 cumulatively describes the most important molecular signaling pathways that are affected by reactive oxygen species (ROS). These are the mechanisms which are common denominators in various pathological states. In the next part of the book, various antioxidant strategies to target and mitigate ROS have been discussed with details on the mechanisms. Selenium, being the research focus and interest of the authors for years, the role of selenium as an antioxidant as part of selenoproteins has been included in the book. Finally, the book culminates with authors’ perspective on the future of the redox biology field. Throughout the book, efforts have been made to use simplified language and suitable figures for ease to understand the contents. Although the authors have tried to touch on all the different aspects of oxidative stress in detail, the fact that it is a continuously growing field with updates coming every day, there might be some areas which might not be described in depth. This book is designed for students, young scientists to get acquainted with the redox biology. Overall, this book is a reference to understand the redox regulation of cellular signaling pathways involved in pathogenesis.
Author: Conor Reilly
Publisher: Springer Science & Business Media
Release Date: 2013-03-09
Genre: Technology & Engineering
This book provides readers with a clear and reliable account of the extraordinary story of selenium and its role in human health. It is written in a readable and user-friendly manner, and takes into account the considerable amount of fresh information that has been published over the past decade. The book if for the reader who wants to make an informed judgment about the competing claims for and against Selenium’s value as a nutritional supplement.
Insightful, objective, and evidence-based, this overview of the most commonly used supplements dispels misinformation and provides facts from a qualified physician's point of view. • Provides coverage of 39 different supplements, including vitamin D, omega-3 fatty acids, biotin, vitamin B12, iron, calcium, and coenzyme Q10 • Supplies a thorough and evidence-based examination of the facts and fiction behind supplements • Includes a bibliography containing over 1,000 medical references
This volume, along with its companion (volume 474), presents methods and protocols dealing with thiol oxidation-reduction reactions and their implications as they relate to cell signaling. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Over 450 volumes have been published to date, and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Along with companion volume, provides a full overview of techniques necessary to the study of thiol redox in relation to cell signaling Gathers tried and tested techniques from global labs, offering both new and tried-and-true methods Relevant background and reference information given for procedures can be used as a guide to developing protocols in a number of disciplines
Thiol Redox Transitions in Cell Signaling, Part A, along with its companion (volume 475), presents methods and protocols dealing with thiol oxidation-reduction reactions and their implications as they relate to cell signaling. This first installment of Cadenas and Packer's two-volume treatment specifically deals with glutathionylation and dethiolation, and peroxide removal by peroxiredoxins/thioredoxins and glutathione peroxidases. The critically acclaimed laboratory standard for 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Over 450 volumes have been published to date, and much of the material is relevant even today--truly an essential publication for researchers in all fields of life sciences. Along with companion volume, provides a full overview of techniques necessary to the study of thiol redox in relation to cell signaling Gathers tried and tested techniques from global labs, offering both new and tried-and-true methods Relevant background and reference information given for procedures can be used as a guide to developing protocols in a number of disciplines
Advances in Microbial Physiology is one of the most successful and prestigious series from Academic Press, an imprint of Elsevier. It publishes topical and important reviews, interpreting physiology to include all material that contributes to our understanding of how microorganisms and their component parts work. First published in 1967, the editors have always striven to interpret microbial physiology in the broadest context and have never restricted the contents to “traditional views of whole cell physiology. Now edited by Professor Robert Poole, University of Sheffield, Advances in Microbial Physiology continues to be an influential and very well reviewed series.
Author: Benjamin Caballero
Publisher: Academic Press
Release Date: 2005
Genre: Health & Fitness
"This encyclopedia contains signed articles with bibliographies written by an international group of distinguished academics, research scientists, and food-industry professionals. The alphabetical entries cover the scientific, political, and social aspects of nutrition. Among the subjects included are individual nutrients and foods, anatomy and physiology, nutritional therapy for diseases and conditions, and subjects such as nutritional management of refugees, nutrition education, religious customs, and folklore. Appendixes with charts of weights and measures, nutritional allowances, and nutritional content of foods appear in each volume. In-depth coverage of the scientific, political, and social aspects of nutrition set this work apart from other reference sources in the field."--"Outstanding reference sources 2000", American Libraries, May 2000. Comp. by the Reference Sources Committee, RUSA, ALA.
Author: J. Beuth
Publisher: Thieme Medical Publishers
Release Date: 2006
Patients with the diagnosis "cancer" are increasingly asking for complementary procedures in the treatment of their disease. About 80% of all cancer patients are using complementary measures, frequently without the knowledge of the attending oncologist. Physicians and therapists therefore urgently need information on methods in complementary oncology that have been evaluated for efficacy. This book presents, for the first time, the integration of established complementary medical procedures into oncological treatment plans. Practicing oncologists will appreciate the book's accessible layout and well-organized tables when using the book as a reference work for quick answers and as a resource when counseling cancer patients. For oncologists involved in scientific research this book provides a comprehensive, critical insight into relevant research findings. Based on the criteria of evidence-based medicine (EBM), the book presents reliable information on complementary oncological procedures and straightforward treatment plans - which are always combined with the approved standard therapies and can be directly put into practice. An overview of reliable information on complementary methods in oncology Straightforward treatment plans for the practice A competent guide when counseling cancer patients.
Since the last edition was published in 1991, the 'Merian' has established itself as the standard reference on this topic, and remains unmatched in the breadth of material covered. This new edition is more clearly and concisely structured, and more emphasis is now given to nutritional aspects of the elements. It continues to provide: Detailed information on the environmental metals that influence the health of plants, animals and humans Describes the problems related to waste, soils and wildlife as well as the risks caused by the increasing output of metals from industry and households An extensive bibliography, numerous tables with useful data and a glossary of terms International experts from 15 countries have pooled their knowledge and experience to create this ultimate resource giving essential information to all chemists, biologists, geologists, food scientists, toxicologists and physiologists involved in environmental research and remediation, risk assessment, food research and industrial hygiene.
Author: J. Larry Jameson
Publisher: Elsevier Health Sciences
Release Date: 2010-05-18
ENDOCRINOLOGY, edited by J. Larry Jameson, MD, PhD and Leslie J. De Groot, MD, has been considered the definitive source in its field for decades. Now this landmark reference has been exhaustively updated to bring you the latest clinical guidance on all aspects of diagnosis and treatment for the full range of endocrine and metabolism disorders, including new information on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors. Entirely new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis keep you well informed on today’s hot topics. You’ll benefit from unique, global perspectives on adult and pediatric endocrinology prepared by an international team of renowned authorities. This reference is optimally designed to help you succeed in your demanding practice and ensure the best possible outcomes for every patient. Overcome virtually any clinical challenge with detailed, expert coverage of every area of endocrinology, authored by hundreds of leading luminaries in the field. Provide state-of-the-art care with comprehensive updates on diabetes, obesity, MEN I and II, disorders of sex determination, and pituitary tumors ... brand-new chapters on Lipodystrophy Syndromes, Lipoprotein Metabolism, and Genetic Disorders of Phosphate Homeostasis ... expanded coverage of sports performance, including testosterone, androgen research, and bone growth and deterioration ... and the newest discoveries in genetics and how they affect patient care. Make the best clinical decisions with an enhanced emphasis on evidence-based practice in conjunction with expert opinion. Rapidly consult with trusted authorities thanks to new expert-opinion treatment strategies and recommendations. Zero in on the most relevant and useful references with the aid of a more focused, concise bibliography. Locate information more quickly, while still getting the complete coverage you expect.