Aromaticity in Heterocyclic Compounds

Author: Tadeusz Marek Krygowski
Publisher: Springer Science & Business Media
ISBN: 9783540683292
Release Date: 2009-01-30
Genre: Science

Heterocyclic chemistry is the biggest branch of chemistry covering two-thirds of the chemical literature. Aromaticity in Heterocyclic Compounds covers hot topics of frontier research summarized by reputed scientists in the field.

Phosphorus Heterocycles II

Author: Raj K. Bansal
Publisher: Springer Science & Business Media
ISBN: 9783642122538
Release Date: 2010-04-30
Genre: Science

Contents: S. Sasaki: Heterophenes Carrying Phosphorus Functional Groups as Key Structures.- D.D. Enchev: Synthesis and Biological Activity of 2,5-Dihydro-1,2-Oxaphosphole-2-Oxide Derivatives.- D. Gudat: Recent Developments in the Chemistry of N -Heterocyclic Phosphines.- J. Drabowicz ∙ D. Krasowska ∙ A. Łopusiński ∙T.S.A. Heugebaert ∙ C.V. Stevens: Selected Five-Membered Phosphorus Heterocycles Containing a Stereogenic Phosphorus.- G. Keglevich: 1-(2,4,6-Trialkylphenyl)-1 H -Phospholes with a Flattened P-Pyramid: Synthesis and Reactivity.- N. Gupta: Recent Advances in the Chemistry of Diazaphospholes

Flow Chemistry for the Synthesis of Heterocycles

Author: Upendra K. Sharma
Publisher: Springer
ISBN: 9783319943282
Release Date: 2018-08-29
Genre: Science

This volume provides an overview of recent developments and scope in the use of flow chemistry in relevance to heterocyclic synthesis. The heterocyclic ring is the most prominent structural motif in the vast majority of natural products as well as pharmaceutical compounds since this facilitates tuneable interactions with the biological target besides conferring a degree of structural and metabolic stability. In recent times, flow chemistry has heralded a paradigm shift in organic synthesis as it offers several unique advantages over conventional methods like drastic acceleration of sluggish transformations, enhanced yields, cleaner reactions etc and is gradually gaining a lot of attention among organic chemist worldwide. Given the importance of heterocycles in natural products, medicinal chemistry and pharmaceuticals, this is a well warranted volume and complements the previous volume of Topics in Organometallic Chemistry ‘Organometallic Flow Chemistry’. This volume offers a versatile overview of the topic, besides discussing the recent progress in the flourishing area of flow chemistry in relevance to heterocyclic chemistry; it will also help researchers to better understand the chemistry behind these reactions. This in turn provides a platform for future innovations towards the designing of novel transformations under continuous flow. Thus, this volume will appeal to both the novices in this field as well as to experts in academia and industry.

Free Radical Synthesis and Functionalization of Heterocycles

Author: Yannick Landais
Publisher: Springer
ISBN: 9783319895215
Release Date: 2018-05-03
Genre: Science

This volume describes the recent developments in the free-radical mediated synthesis and elaboration of heterocycles. The first chapter, dealing with radical cascade processes illustrates the power and the beauty of radical chemistry with some striking examples of total synthesis of complex natural heterocycles. As organic chemists strive towards sustainability, radical chemistry has recently seen major advances and efforts in this direction, including C-H activation of arenes and unactivated alkyl groups. Photochemical activation, for a long time the preferred mode of activation in radical chemistry has also seen an unexpected revival with the advent of visible light metal- and organocatalyzed photoredox processes. A survey of these emerging areas is provided along with the concepts at the origin of these developments. The venerable Minisci reaction allows for direct access to functionalized heterocycles. This process has lately seen an interesting renaissance and is discussed in this volume. Addition of heteroatom-centered radicals onto unsaturated systems constitutes another powerful method to construct heterocycles. Examples of such a strategy are proposed along with the formation of various heterocycles relying on homolytic substitution at sulfur, phosphorus and selenium. Additionally free-radical functionalization of reactive functional groups including isonitriles, isothiocyanates and related unsaturated systems which offer a straightforward route towards useful aromatic and non-aromatic heterocycles are discussed. Finally, as metals are able to trigger single electron transfer both in reductive and oxidative modes this provides another possibility for the synthesis of heterocycles. Significant research efforts have focused on the use of samarium, copper and other metals to access a broad variety of heterocycles in a single pot process, starting from readily available raw material. Examples and mechanistic insights are discussed by experts in this area.

Phosphorus

Author: D.E.C. Corbridge
Publisher: CRC Press
ISBN: 9781439840887
Release Date: 2013-01-07
Genre: Science

Over two decades have passed since the fifth edition of Phosphorus: Chemistry, Biochemistry and Technology. Major advances in chemistry, materials science, electronics, and medicine have expanded and clarified the role of phosphorus in both our everyday appliances and groundbreaking research. Significantly expanded, updated, and reorganized, this sixth edition organizes and explains vital phosphorus research and relevant information available in highly specialized reviews and references on select related topics. An authoritative and comprehensive review of phosphorus chemistry and related technology, Phosphorus: Chemistry, Biochemistry and Technology covers historical, academic, industrial, agricultural, military, biological, and medical aspects of phosphorous. Furthermore, it offers a starting point for more extended studies of the highly specialized branches of phosphorus chemistry. Although this book deals with a small fraction of the > 106 known phosphorus compounds, it thoroughly covers the simpler derivatives and most key compounds of economic, sociological, and biological importance. Extensively updated and expanded with tables, figures, equations, structural formulae, and references, it is ideal for scientists in related fields seeking a rapid introduction to phosphorus chemistry.

The Chemistry of Heterocycles

Author: Vishnu Ji Ram
Publisher: Elsevier
ISBN: 9780081011911
Release Date: 2017-09-01
Genre: Science

The Chemistry of Heterocycles: Structure, Activity, and Applications provides a detailed guide to the chemistry, behavior, and potential of these important structures. Beginning with an introduction to the topic, the book presents a practical guide to international nomenclature, including discussions of fused ring systems, heteroatoms with abnormal valences, and bridged, spiro, and polycyclic heterocycles. Three membered heterocycles are then the focus of Chapter Three, where structural and thermodynamic properties, importance in natural products, medicines, and materials, and important aspects, such as strain, basicity, and reactivity of three membered nitrogen heterocycles are discussed. Chapters Four through Eight follow the same format, covering over 100 key heterocycle structures, from Azetidines, Pyrroles and Pyridines, to Benzoxepines and Oxocanes. Finally, Chapter Nine explores cutting-edge advances in the development of Phosphorous and Selenium based heterocycles. Drawing on the expert knowledge of its highly experienced authors, the book is a practical tool for all those studying and working with heterocycles across a range of disciplines. Provides clear, detailed information on each heterocyclic group, including structural features, such as ring strain, basicity, synthesis, and reactivity towards electrophilic and nucleophilic reagents Highlights the latest advances in the field, including phosphorous and selenium-based heterocycles that are supported by numerous illustrations Includes details of functionalized heterocycles used as synthons for the construction of various arenes and heteroarenes

Progress in Heterocyclic Chemistry

Author: G.W. Gribble
Publisher: Elsevier
ISBN: 0080539866
Release Date: 2000-11-17
Genre: Science

This volume of Progress in Heterocyclic Chemistry (PHC) is the twelfth annual review of the literature, covering the work published on most of the important heterocyclic ring systems during 1999, with inclusions of earlier material as appropriate. As in PHC-11, there are also three specialized reviews in this year's volume. In the inaugural chapter, Michael Groziak revitalizes the field of boron heterocycles, a relatively obscure class of heterocycles, but with a promising future. Heterocyclic phosphorus ylides are similarly a little known but useful class of compounds and Alan Aitken and Tracy Massil have provided a comprehensive review of them in Chapter 2. In Chapter 3 Jack Li discusses the remarkably versatile palladium chemistry in pyridine alkaloid synthesis. The subsequent chapters deal with recent advances in the field of heterocyclic chemistry arranged by increasing ring size and with emphasis on synthesis and reactions.

Advances in Heterocyclic Chemistry

Author: Alan R. Katritzky
Publisher: Academic Press
ISBN: 9780124046436
Release Date: 2012-12-25
Genre: Science

Established in 1960, Advances in Heterocyclic Chemistry is the definitive serial in the area—one of great importance to organic chemists, polymer chemists and many biological scientists. Written by established authorities in the field, the comprehensive reviews combine descriptive chemistry and mechanistic insight and yield an understanding of how the chemistry drives the properties. Provides up-to-date material on a fast-growing and highly topical subject area Contains the latest research covering a wide variety of heterocyclic topics Written by leading authorities and designed as a handbook for students and industry and academic researchers

Fundamentals of Heterocyclic Chemistry

Author: Louis D. Quin
Publisher: John Wiley & Sons
ISBN: 0470626534
Release Date: 2010-07-08
Genre: Science

Heterocyclic chemistry is of prime importance as a sub-discipline of Organic Chemistry, as millions of heterocyclic compounds are known with more being synthesized regularly Introduces students to heterocyclic chemistry and synthesis with practical examples of applied methodology Emphasizes natural product and pharmaceutical applications Provides graduate students and researchers in the pharmaceutical and related sciences with a background in the field Includes problem sets with several chapters

Phosphorus Chemistry I

Author: Jean-Luc Montchamp
Publisher: Springer
ISBN: 9783319154732
Release Date: 2015-03-06
Genre: Science

Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field.

Fluorine in Heterocyclic Chemistry Volume 2

Author: Valentine Nenajdenko
Publisher: Springer
ISBN: 3319044346
Release Date: 2014-07-28
Genre: Science

This two-volume work combines comprehensive information on the chemistry of the fluorinated heterocycles. The material has been divided such that the first volume is dedicated to 5-membered fluorinated heterocycles and macrocycles, while the second volume combines data connected with the chemistry of fluorine containing 6-membered heterocycles. Both volumes will be of interest to synthetic organic chemists in general, and particularly for those colleagues working in the fields of heterocyclic-compound chemistry, materials chemistry, medicinal chemistry, and fluorine chemistry. All information is presented and classified clearly to be effective source for broad auditory of chemists. It will be interesting for scientists working in the field of inorganic and coordination chemistry. Fluorinated heterocycles are becoming increasingly important in many areas including the pharmaceutical industry, materials science and agriculture. The presence of fluorine can result in substantial functional changes in the biological as well as physicochemical properties of organic compounds. Incorporation of fluorine into drug molecules can greatly affect their physicochemical properties, such as bond strength, lipophilicity, bioavailability, conformation, electrostatic potential, dipole moment, pKa etc. as well as pharmacokinetic properties, such as tissue distribution, rate of metabolism and pharmacological properties, such as pharmacodynamics and toxicology.

Progress in Heterocyclic Chemistry

Author: Gordon W. Gribble
Publisher: Elsevier
ISBN: 9780080968056
Release Date: 2011
Genre: Science

Progress in Heterocyclic Chemistry (PHC) is an annual review series commissioned by the International Society of Heterocyclic Chemistry (ISHC). Volumes in the series contain both highlights of the previous year's literature on heterocyclic chemistry and articles on emerging topics of particular interest to heterocyclic chemists. The chapters in Volume 23 constitute a systematic survey of the important original material reported in the literature of heterocyclic chemistry in 2010. As with previous volumes in the series, Volume 23 apprises academic/industrial chemists and advanced students of developments in heterocyclic chemistry in a convenient format. Covers the heterocyclic literature published in 2010 Includes specialized reviews Features contributions from leading researchers in their fields