Personalized Immunosuppression in Transplantation

Author: Michael Oellerich
Publisher: Elsevier
ISBN: 9780128011331
Release Date: 2015-08-08
Genre: Medical

Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring. The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity. This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful. Focuses on the personalized management of immunosuppression therapy in individual transplant patients Presents information that applies to many areas, including gmass spectrometry, assay design, assay validation, clinical chemistry, and clinical pathology Provides practical guidelines for the initial selection and subsequent modifications of immunosuppression therapy in individual transplant patients Reviews the latest research in biomarker monitoring in personalizing immunosuppressant therapy, including potential new markers not currently used, but with great potential for future use Explains how monitoring graft-derived, circulating, cell free DNA has shown promise in the early detection of transplant injury in liquid biopsy

Gastrointestinal Transplantation An Issue of Gastroenterology Clinics of North America E Book

Author: Enrico Benedetti
Publisher: Elsevier Health Sciences
ISBN: 9780323584029
Release Date: 2018-05-16
Genre: Medical

The Guest Editors have put together a concise monograph on the latest advances in transplantation of the liver, intestine, and pancreas. Expert authors have written comprehensive reviews on the following topics: Living donor liver transplantation: Technical innovations; Liver transplantation for cholangiocarcinoma; Immunological monitoring to personalize immunosuppression after liver transplantation; Status of adult LDLT in US based on A2ALL; Pediatric liver transplantation; Modern treatment of fulminant liver failure; Intestinal failure and rehabilitation; Adult intestinal transplantation; Pediatric intestinal transplantation; Living donor intestinal transplantation; Endoscopic follow-up of intestinal transplant recipients; Multivisceral transplantation; Pancreas transplantation for DM1 and DM2; and Robotic pancreas transplantation. Readers will come away with the clinical information they need to stay current on issues surrounding gastrointestinal transplantations.

Therapeutic Drug Monitoring

Author: Amitava Dasgupta
Publisher: Academic Press
ISBN: 9780123854681
Release Date: 2012-06-07
Genre: Medical

Therapeutic Drug Monitoring: Newer Drugs and Biomarkers features timely topics such as the monitoring of classical and newer drugs, pharmacogenomics and the application of biomarkers in therapeutic drug monitoring. This reference also discusses the limitations of current commercially available immunoassays for therapeutic monitoring. It presents new and sophisticated techniques used for proper determination of blood levels and the clinical utility of therapeutic drug monitoring of contemporary drugs. Written by leading international experts and geared toward clinical pathologists, toxicologists, clinical chemists, laboratory professionals and physicians, this book is an essential resource on the current practice of therapeutic drug monitoring in improving patient safety. Includes both the technical and clinical issues associated with therapeutic drug monitoring Discusses the utility of therapeutic drug monitoring of newer drugs such as antiretroviral agents, anticonvulsants, antidepressants etc. Provides up-to-date information on issues in pharmacogenomics and personalized medicine with emphasis on therapy with warfarin, certain anticancer drugs and antidepressants Covers important content on the limitations of commercially available immunoassays (chemical tests) for therapeutic drug monitoring and additional analytical techniques

Textbook of Organ Transplantation Set

Author: Allan D. Kirk
Publisher: John Wiley & Sons
ISBN: 9781118889626
Release Date: 2014-07-21
Genre: Medical

Brought to you by the world’s leading transplantclinicians, Textbook of Organ Transplantation provides acomplete and comprehensive overview of modern transplantation inall its complexity, from basic science to gold-standard surgicaltechniques to post-operative care, and from likely outcomes toconsiderations for transplant program administration, bioethics andhealth policy. Beautifully produced in full color throughout, and with over 600high-quality illustrations, it successfully: Provides a solid overview of what transplantclinicians/surgeons do, and with topics presented in an order thata clinician will encounter them. Presents a holistic look at transplantation, foregrounding theinterrelationships between transplant team members and non-surgicalclinicians in the subspecialties relevant to pre- andpost-operative patient care, such as gastroenterology, nephrology,and cardiology. Offers a focused look at pediatric transplantation, andidentifies the ways in which it significantly differs fromtransplantation in adults. Includes coverage of essential non-clinical topics such astransplant program management and administration; research designand data collection; transplant policy and bioethical issues. Textbook of Organ Transplantation is the market-leadingand definitive transplantation reference work, and essentialreading for all transplant surgeons, transplant clinicians, programadministrators, basic and clinical investigators and any othermembers of the transplantation team responsible for the clinicalmanagement or scientific study of transplant patients.

Issues in Medical Chemistry 2013 Edition

Publisher: ScholarlyEditions
ISBN: 9781490107561
Release Date: 2013-05-01
Genre: Medical

Issues in Medical Chemistry / 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Physiology and Biochemistry. The editors have built Issues in Medical Chemistry: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Physiology and Biochemistry in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Medical Chemistry: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at

Tietz Textbook of Clinical Chemistry and Molecular Diagnostics E Book

Author: Carl A. Burtis
Publisher: Elsevier Health Sciences
ISBN: 9781455759422
Release Date: 2012-10-14
Genre: Medical

As the definitive reference for clinical chemistry, Tietz Textbook of Clinical Chemistry and Molecular Diagnostics, 5th Edition offers the most current and authoritative guidance on selecting, performing, and evaluating results of new and established laboratory tests. Up-to-date encyclopedic coverage details everything you need to know, including: analytical criteria for the medical usefulness of laboratory procedures; new approaches for establishing reference ranges; variables that affect tests and results; the impact of modern analytical tools on lab management and costs; and applications of statistical methods. In addition to updated content throughout, this two-color edition also features a new chapter on hemostasis and the latest advances in molecular diagnostics. Section on Molecular Diagnostics and Genetics contains nine expanded chapters that focus on emerging issues and techniques, written by experts in field, including Y.M. Dennis Lo, Rossa W.K. Chiu, Carl Wittwer, Noriko Kusukawa, Cindy Vnencak-Jones, Thomas Williams, Victor Weedn, Malek Kamoun, Howard Baum, Angela Caliendo, Aaron Bossler, Gwendolyn McMillin, and Kojo S.J. Elenitoba-Johnson. Highly-respected author team includes three editors who are well known in the clinical chemistry world. Reference values in the appendix give you one location for comparing and evaluating test results. NEW! Two-color design throughout highlights important features, illustrations, and content for a quick reference. NEW! Chapter on hemostasis provides you with all the information you need to accurately conduct this type of clinical testing. NEW! Six associate editors, Ann Gronowski, W. Greg Miller, Michael Oellerich, Francois Rousseau, Mitchell Scott, and Karl Voelkerding, lend even more expertise and insight to the reference. NEW! Reorganized chapters ensure that only the most current information is included.

Brenner and Rector s The Kidney E Book

Author: Maarten W. Taal
Publisher: Elsevier Health Sciences
ISBN: 9781455723041
Release Date: 2011-11-01
Genre: Medical

Overcome the toughest clinical challenges in nephrology with the new 9th edition of Brenner/Rector’s The Kidney! A brand-new editorial team of Drs. Maarten W. Taal, Glenn M. Chertow, Philip A. Marsden, Karl Skorecki, Alan S. L. Yu, and Barry M. Brenner,, together with a diverse list of international contributors bring you the latest knowledge and best practices on every front in nephrology worldwide. Brand-new sections on Global Considerations in Nephrology and Pediatric Nephrology, as well as new chapters on recent clinical trials, cardiovascular and renal risk prediction in chronic kidney disease, identification of genetic causes of kidney disease, and many others, keep you at the forefront of this rapidly growing, ever-changing specialty. Brenner/Rector remains the go-to resource for practicing and training nephrologists and internists who wish to master basic science, pathophysiology, and clinical best practices. Broaden your knowledge base with expert, dependable, comprehensive answers for every stage of your career from the most comprehensive, definitive clinical reference in the field! Prepare for certification or recertification with a review of the basic science that underpins clinical nephrology as well as a comprehensive selection of the most important bibliographical sources in nephrology. Visually grasp and better understand critical information with the aid of over 700 full-color high-quality photographs as well as carefully chosen figures, algorithms, and tables to illustrate essential concepts, nuances of clinical presentation and technique, and decision making. Get internationally diverse, trusted guidance and perspectives from a team of well-respected global contributors, all of whom are at the top and the cutting edge of your field. A new editorial team headed by Dr. Taal and hand-picked by Dr. Brenner ensures the ongoing adherence to previous standards of excellence. Access information quickly thanks to a new, reorganized format and supplemental figures, tables, additional references, and expanded discussions. Keep current with the rapid development of care and research worldwide. A new section, "Global Considerations", focuses on regions outside Europe and North America. Leading experts from Latin America, Africa, Near and Middle East, Indian Subcontinent, Far East, Oceania and Australia present their expert insights into specific conditions, as well as progress and challenges in the development of the specialty. Improve therapy and outcomes for children with renal disease. New to this edition, "Pediatric Nephrology" addresses renal pathologies that usually present in childhood and covers topics such as Maturation of Kidney Structure and Function; Fluid; Electrolyte and Acid-Base Disorders in Children; Diseases of the Kidney and Urinary Tract in Children; Dialysis in Children; and Kidney Transplantation in Children. Stay up to date with all the latest clinical information including recent clinical trials, genetic causes of kidney disease, and cardiovascular and renal risk prediction in chronic kidney disease.

Therapie mit Blutkomponenten

Author: F.W. Ahnefeld
Publisher: Springer
ISBN: 3540101802
Release Date: 1980-08-01
Genre: Medical

Über das für dieses Workshop ausgewählte Thema "Therapie mit Blutkomponenten" ist in den zurückliegenden Jahren auf Kongressen und Symposien immer wieder be richtet und diskutiert worden, es entstand eine reichhaltige Literatur. Spezialisten unterschiedlicher Herkunft haben ihre Erkenntnisse dargestellt und Empfehlungen abgegeben. Bei einer kritischen Sichtung der Aussagen beherrschen, wie in der mo demen Wissenschaft immer häufiger, Schlagworte die Szene, die zu entsprechenden Polarisierungen der Auffassungen führten. Auch in diesem Bereich erscheint unter anderem die Klärung der Frage notwendig, was bei Abwägung der Kosten in Relation und Anforderungen sinnvoll und möglich und auf grund der zu den Bedürfnissen Weiterentwicklung der Medizin wünschenswert oder erforderlich ist. Verständlicher weise stehen für die Transfusionsmediziner andere Probleme im Vordergrund als für den Kliniker,ja selbst in diesen beiden Gruppen bewirken unterschiedliche Voraus setzungen, wie sie bei örtlichen und regionalen Blutspendediensten bestehen, oder auch ein unterschiedliches Krankengut Kontroversen oder zumindest andere Bewer tungsmaßstäbe. Ohne einen ständigen Erfahrungsaustausch und eine enge Kooperation ist die Lösung der anstehenden Probleme nicht möglich. Experten sind heute nicht nur aufgerufen, die Weiterentwicklung auf allen medizinischen Gebieten voranzutreiben, sie müssen in Zwischenbilanzen auch überprüfen, ob sich ihre Vorstellungen im klini schen Alltag, also an jedem Krankenhaus, realisieren lassen. Ohne eine solche kritische Bestandsaufnahme reden wir eher aneinander vorbei; die von allen gewünschte positive Entwicklung wird durch eine Verunsicherung ersetzt. Wir dürfen insbesondere nicht vergessen, daß sich unsere Aufgaben, z. B. in der operativen Medizin, in den letzten zehn Jahren weiter und wesentlich verändert haben.

Pharmacotherapy A Pathophysiologic Approach Tenth Edition

Author: Joseph T. DiPiro
Publisher: McGraw Hill Professional
ISBN: 9781259587498
Release Date: 2017-01-23
Genre: Medical

The most comprehensive text available on the use of evidence-based medication therapies for optimal patient outcomes – updated with the latest breakthroughs and guidelines A Doody's Core Title for 2017! Pharmacotherapy: A Pathophysiologic Approach is written to help you advance the quality of patient care through evidence-based medication therapy derived from sound pharmacotherapeutic principles. The scope of this trusted classic goes beyond drug indications and dosages to include the initial selection, proper administration, and monitoring of drugs. You will find everything you need to provide safe, effective drug therapy across the full range of therapeutic categories. Presented in full-color, the Tenth Edition is enriched by more than 300 expert contributors, and every chapter has been updated to reflect the latest in evidence-based information and recommendations. This sweeping updates include tables, charts, algorithms, and practice guidelines. This edition is also enhanced by a timely all-new chapter on Travel Health. Here’s why this is the perfect learning tool for students, patient-focused pharmacists, and other health care providers: • All chapters have been updated to provide the most current, reliable, and relevant information possible • Key Concepts at the beginning of each chapter • Clinical Presentation Tables summarize disease signs and symptoms • Clinical Controversies Boxes examine the complicated issues faced by students and clinicians in providing drug therapy • Color coded diagnostic flow diagram, treatment algorithms, dosing recommendations, and monitoring approaches clearly distinguish treatment pathways • Most disease-oriented chapters include updated evidence-based treatment guidelines that often include ratings of the level of evidence to support the key therapeutic approaches Edition after trusted edition, Pharmacotherapy: A Pathophysiologic Approach has been unmatched in its ability to clearly and impartially impart core pathophysiological and therapeutic elements that students and practitioners must be familiar with.


Author: M. Meisner
Publisher: Georg Thieme Verlag
ISBN: 3131055030
Release Date: 2000-01

This work provides specific infection parameters for bacterial infections, and indicators for the inflammatory activity of sepsis and multi-organ failure.

Pharmacotherapy A Pathophysiologic Approach 9 E

Author: Joseph T. DiPiro
Publisher: McGraw Hill Professional
ISBN: 9780071800549
Release Date: 2014-03-22
Genre: Medical

25 ADDITIONAL CHAPTERS AVAILABLE ONLINE THE LANDMARK TEXT ON HOW TO ACHIEVE OPTIMAL PATIENT OUTCOMES THROUGH EVIDENCE-BASED MEDICATION THERAPY Pharmacotherapy: A Pathophysiologic Approach is written to help you advance the quality of patient care through evidence-based medication therapy derived from sound pharmacotherapeutic principles. The scope of this trusted classic goes beyond drug indications and dosages to include the initial selection, proper administration, and monitoring of drugs. You will find everything you need to provide safe, effective drug therapy across the full range of therapeutic categories. This edition is enriched by more than 300 expert contributors, and every chapter has been revised and updated to reflect the latest evidence-based information and recommendations. Important features such as Key Concepts at the beginning of each chapter, Clinical Presentation tables that summarize disease signs and symptoms, and Clinical Controversies boxes that examine the complicated issues faced by students and clinicians in providing drug therapy make this text an essential learning tool for students, patient-focused pharmacists, and other health care providers. NEW TO THIS EDITION: A section on personalized pharmacotherapy appears in most sections All diagnostic flow diagrams, treatment algorithms, dosing guideline recommendations, and monitoring approaches have been updated in full color to clearly distinguish treatment pathways New drug monitoring tables have been added Most of the disease-oriented chapters have incorporated evidence-based treatment guidelines that often include ratings of the level of evidence to support the key therapeutic approaches Twenty-five online-only chapters are available at