Lipid Metabolism in Signaling Systems

Author: John N. Fain
Publisher: Academic Press
ISBN: 9781483288321
Release Date: 2013-10-22
Genre: Science

Many of the phospholipases and even the receptor for inositol 1,4,5-trisphosphate have recently been cloned and sequenced and play an important role in neurotransmission. Methods developed in recent years for the study of the enzymes and intermediates involved in the regulation of neuronal signal transduction involving phospholipid turnover are presented in this volume. Techniques for examining the role of phosphoinositides in signal transduction Techniques related to protein kinase C Analysis of inositol phosphates Techniques to analyze phospholipid turnover in the brain

Inositol Phospholipid Metabolism and Phosphatidyl Inositol Kinases

Author: Arnis Kuksis
Publisher: Elsevier
ISBN: 9780444513212
Release Date: 2003
Genre: Science

Offers a review of developments along with tried and tested methods for isolation, resolution and quantification of inositol phospholipids and inositol polyphosphates in both cells and tissues. This book includes detailed methodology for identification of molecular species of inositol phospholipids, including their phosphates and glycans.

Providing Pharmacological Access to the Brain

Author: Thomas R. J. Flanagan
Publisher:
ISBN: UVA:X002540078
Release Date: 1994
Genre: Blood-brain barrier

This volume focuses on contemporary approaches for delivering experimental and therapeutic agents into the brain. The contributions provide methodological details that are typically not available in the literature. Subtleties and shortcuts critical to each procedure are included to facilitate their use by both the experienced researcher and novice. Highlights * Polymeric, cellular, and molecular drug delivery * Neuropharmacology * Blood-brain barrier * Central nervous system

Neurobiology of Cytokines

Author: Errol B. De Souza
Publisher: Academic Press
ISBN: 9781483217550
Release Date: 2013-10-22
Genre: Health & Fitness

Neurobiology of Cytokines, Part A provides an overview of the effects of cytokines in the brain and in the endocrine system. The book discusses the general aspects of cytokines, including the endogenous agonists and antagonists, their receptors, their second messengers, and transport mechanisms for cytokines across the blood-brain barrier. The text also describes the anatomical localization of cytokines, cytokine receptors, and their respective mRNA in brain and in endocrine tissues. The methods for evaluating the in vivo as well as in vitro actions of cytokines on hormone secretion are also considered. The book further tackles the synthesis and release of cytokines and their central nervous system actions; and the methodology for studying the role of cytokines in human neuropathological conditions.

Pulsatility in Neuroendocrine Systems

Author: Jon E. Levine
Publisher: Academic Press
ISBN: 9781483288345
Release Date: 2013-10-22
Genre: Science

Pulsatility is now recognized as a nearly ubiquitous functional feature of neuroendocrine systems. This volume presents a comprehensive guide to the established and emerging technologies being used to study the perplexing phenomenon of pulsatility. Molecular, cellular, physiological, and mathematical approaches are described in detail. In vitro methods for studying neuroendocrine pulsatility In vivo sampling and recording procedures for monitoring pulsatility in several species Improved quantitative and analytical methods for the study of hormone pulsatility

Fundamental Neuroscience

Author: Larry R. Squire
Publisher: Academic Press
ISBN: 9780123858702
Release Date: 2013
Genre: Medical

Fundamental Neuroscience, 3rd Edition introduces graduate and upper-level undergraduate students to the full range of contemporary neuroscience. Addressing instructor and student feedback on the previous edition, all of the chapters are rewritten to make this book more concise and student-friendly than ever before. Each chapter is once again heavily illustrated and provides clinical boxes describing experiments, disorders, and methodological approaches and concepts. A companion web site contains test questions, and an imagebank of the figures for ready use in presentations, slides, and handouts. Capturing the promise and excitement of this fast-moving field, Fundamental Neuroscience, 3rd Edition is the text that students will be able to reference throughout their neuroscience careers! New to this edition: * 30% new material including new chapters on Dendritic Development and Spine Morphogenesis, Chemical Senses, Cerebellum, Eye Movements, Circadian Timing, Sleep and Dreaming, and Consciousness * Companion website with figures, web links to additional material, and test questions * Additional text boxes describing key experiments, disorders, methods, and concepts * Multiple model system coverage beyond rats, mice, and monkeys * Extensively expanded index for easier referencing

PCR in Neuroscience

Author: Gobinda Sarkar
Publisher:
ISBN: 0121852962
Release Date: 1995
Genre: Neurosciences

The volumes in this series include contemporary techniques significant to a particular branch of neuroscience. They are an invaluable aid to the student as well as the experienced researcher not only in developing protocols in neuroscience but in disciplines where research is becoming closely related to neuroscience. Each volume of Methods in Neurosciences contains an index, and each chapter includes references. Dr. Conn became Editor-in-Chief of the series beginning with Volume 15, so each subsequent volume could be guest-edited by an expert in that specific field. This further strengthens the depth of coverage in Methods in Neurosciences for students and researchers alike. Key Features * Direct application of PCR to fresh or frozen clinical specimens (e.g., blood and solid tissue) * Complete retrieval of novel expressed genes by PCR without screening a library * Quantitation by PCR * Mutagenesis by PCR * PCR in AIDS research * Simple and effective protocols for PCR on archival specimens.

Fat Detection

Author: Jean-Pierre Montmayeur
Publisher: CRC Press
ISBN: 1420067761
Release Date: 2009-09-14
Genre: Science

Presents the State-of-the-Art in Fat Taste Transduction A bite of cheese, a few potato chips, a delectable piece of bacon – a small taste of high-fat foods often draws you back for more. But why are fatty foods so appealing? Why do we crave them? Fat Detection: Taste, Texture, and Post Ingestive Effects covers the many factors responsible for the sensory appeal of foods rich in fat. This well-researched text uses a multidisciplinary approach to shed new light on critical concerns related to dietary fat and obesity. Outlines Compelling Evidence for an Oral Fat Detection System Reflecting 15 years of psychophysical, behavioral, electrophysiological, and molecular studies, this book makes a well-supported case for an oral fat detection system. It explains how gustatory, textural, and olfactory information contribute to fat detection using carefully designed behavioral paradigms. The book also provides a detailed account of the brain regions that process the signals elicited by a fat stimulus, including flavor, aroma, and texture. This readily accessible work also discusses: The importance of dietary fats for living organisms Factors contributing to fat preference, including palatability Brain mechanisms associated with appetitive and hedonic experiences connected with food consumption Potential therapeutic targets for fat intake control Genetic components of human fat preference Neurological disorders and essential fatty acids Providing a comprehensive review of the literature from the leading scientists in the field, this volume delivers a holistic view of how the palatability and orosensory properties of dietary fat impact food intake and ultimately health. Fat Detection represents a new frontier in the study of food perception, food intake, and related health consequences.

Cognitive Neuroscience of Aging

Author: Roberto Cabeza
Publisher: Oxford University Press
ISBN: 9780190660239
Release Date: 2016-10-31
Genre: Medical

This second edition of the popular Cognitive Neuroscience of Aging provides up-to-date coverage of the most fundamental topics in this discipline. Like the first edition, this volume accessibly and comprehensively reviews the neural mechanisms of cognitive aging appropriate to both professionals and students in a variety of domains, including psychology, neuroscience, neuropsychology, neurology, and psychiatry. The chapters are organized into three sections. The first section focuses on major questions regarding methodological approaches and experimental design. It includes chapters on structural imaging (MRI, DTI), functional imaging (fMRI), and molecular imaging (dopamine PET, etc), and covers multimodal imaging, longitudinal studies, and the interpretation of imaging findings. The second section concentrates on specific cognitive abilities, including attention and inhibitory control, executive functions, memory, and emotion. The third section turns to domains with health and clinical implications, such as the emergence of cognitive deficits in middle age, the role of genetics, the effects of modulatory variables (hypertension, exercise, cognitive engagement), and the distinction between healthy aging and the effects of dementia and depression. Taken together, the chapters in this volume, written by many of the most eminent scientists as well as young stars in this discipline, provide a unified and comprehensive overview of cognitive neuroscience of aging.

Chemosensory Transduction

Author: Frank Zufall
Publisher: Academic Press
ISBN: 9780128017869
Release Date: 2016-02-18
Genre: Science

Written by leaders in the field of chemosensation, Chemosensory Transduction provides a comprehensive resource for understanding the molecular mechanisms that allow animals to detect their chemical world. The text focuses on mammals, but also includes several chapters on chemosensory transduction mechanisms in lower vertebrates and insects. This book examines transduction mechanisms in the olfactory, taste, and somatosensory (chemesthetic) systems as well as in a variety of internal sensors that are responsible for homeostatic regulation of the body. Chapters cover such topics as social odors in mammals, vertebrate and invertebrate olfactory receptors, peptide signaling in taste and gut nutrient sensing. Includes a foreword by preeminent olfactory scientist Stuart Firestein, Chair of Columbia University’s Department of Biological Sciences in New York, NY. Chemosensory Transduction describes state-of-the-art approaches and key findings related to the study of the chemical senses. Thus, it serves as the go-to reference for this subject for practicing scientists and students with backgrounds in sensory biology and/or neurobiology. The volume will also be valuable for industry researchers engaged in the design or testing of flavors, fragrances, foods and/or pharmaceuticals. Provides a comprehensive overview for all chemosensory transduction mechanisms Valuable for academics focused on sensory biology, neurobiology, and chemosensory transduction, as well as industry researchers in new flavor, fragrance, and food testing Edited by leading experts in the field of olfactory transduction Focuses on mammals, but lower vertebrates and invertebrate model systems are also included