Chemotherapeutic Engineering

Author: Feng Si-shen
Publisher: CRC Press
ISBN: 9789814463157
Release Date: 2014-01-17
Genre: Medical

This book is a collection of the major publications of the authors in the emerging area of chemotherapeutic engineering. It describes and demonstrates the concept, feasibility, safety and prospect of chemotherapeutic engineering through a full spectrum of proof-of-concept experiments from design, characterization, in vitro cellular uptake, cytotoxicity, to in vivo pharmacokinetics, biodistribution, and xenograft tumor model of the various nanocarriers, such as prodrugs, micelles, liposomes, and nanoparticles of biodegradable polymers.

Three Daughters Three Journeys

Author: Jill Charles
Publisher: CRC Press
ISBN: 9781351767729
Release Date: 2017-05-18
Genre: Medical

Cancer threatens the lives of people around the world. Women, in particular, are at risk of certain cancers with a genetic cause. Certain mutations in the BRCA1 and BRCA2 genes put mothers and daughters at risk of breast and ovarian cancers. Unlike many cancers that most commonly occur after age 60, these inheritable cancers threaten women’s lives, health and fertility even when they are young, before most would even begin to go for annual mammogram screenings to check for breast cancer. Three Daughters, Three Journeys takes on the biggest health issue of our time from a global perspective with three heroines fighting for their lives against cancer. Marzena, a Polish oncology nurse, has spent her life treating child patients with cancer. Then, she confronts it in her own family and her own body. Kamola, a rural Indian girl, knows she has symptoms of the same disease that took her mother, but feels afraid to discuss it with her father and brothers, knowing her family cannot afford medical treatment. Kamola confides in Dr Rini Mishra, a doctor testing a new treatment called Neelazin, using a bacterial anticancer protein in food, to destroy cancer cells. Selena, a wealthy woman of color in Chicago, finds out about her genetic risks of breast and ovarian cancer. She has a choice of preventative surgery that will save her life but remove any chance of having children. As she meets women who struggle to afford cancer treatment, Selena dedicates her life to providing affordable homes and counseling to families affected by the disease. Although the drug Neelazin is fictional, the possibility of new cancer treatments using bacterial anticancer proteins is being researched now. A problem with the current chemotherapy for cancer treatment is the high toxicity of most of these drugs, as these drugs can enter both normal and cancer cells, though preferably cancer cells, causing the death of normal cells as well that are important in maintaining health. Another problem is that current chemotherapeutic drugs mostly target a single or few key steps that are important for cancer growth and proliferation and inhibit the growth of cancer cells. The cancer cells respond by quickly changing these single targets, thereby becoming resistant to the drugs, as is reflected in stage IV cancer patients. An alternative to chemotherapy would be to exploit the bacterial evolutionary wisdom and use certain proteins that can have preferential entry to cancer cells in order to minimize normal cell toxicity and multiple targets in cancer cells through protein–protein complex formation, thus reducing resistance development in cancer cells. An interesting advantage of protein drugs is to express them as part of food, and some recent research seems to suggest that oral consumption of such foods may allow the therapeutic protein to reach the blood stream to target the cancer. Women with the genetic risk factors could soon have the choice of taking a pill or such anticancer protein-expressing food to treat or prevent cancer, rather than removing the healthy tissue of the breasts and ovaries. Hopefully, they would not have to choose between fertility and survival, as is the implied message in this book, fictional as it is at this time.

Bioadhesion and Biomimetics

Author: Havazelet Bianco-Peled
Publisher: CRC Press
ISBN: 9789814463997
Release Date: 2015-03-02
Genre: Medical

Bioadhesion is often defined as the state in which two materials, at least one of which is biological in nature, are held together for extended periods of time by interfacial forces. It is an area of active multidisciplinary research, where engineers, scientists—including chemists, physicists, biologists, and medical experts—materials’ producers, and manufacturers combine their knowledge. From the practical point of view, bioadhesive systems have been used for several years for medical applications such as dentistry and orthopedics and are now entering new fields, for example, tissue sealing and directed drug delivery systems. Understanding bioadhesion mechanisms is of prime importance while exploring desired adhesion for bioadhesion applications such as sealants as well as successful prevention of undesired adhesion of biomolecules, cells, or organisms. Controlling the occurrence of bioadhesion events is also an important problem in the design and use of medical devices, biosensors, membranes, ships, and oil rigs. This book provides a comprehensive view of bioadhesion and highlights different aspects of this phenomenon. The first section of the book presents fundamentals aspects of bioadhesion. It also summarizes various direct and indirect methods used to investigate and characterize bioadhesion. The second section describes studies of natural adhesives. These include "wet" adhesives that are produced and secreted by sessile marine organisms such as mussels and sand tubes and "dry" adhesives such as the one characterizing the gecko foot. The third section focuses on biomimetic adhesives. These man-made materials are fabricated on the basis of the lessons learned from nature emphasizing the correlation between nature understanding and biomimetics. Finally, the last section reviews medical applications of adhesive materials, which include surgical sealants, mucoadhesive drug delivery vehicles, and prevention of adhesion on medical devices.

Rogue Spooks

Author: Dick Morris
Publisher: St. Martin's Press
ISBN: 9781250167873
Release Date: 2017-08-15
Genre: Political Science

In Rogue Spooks, bestselling authors Dick Morris and Eileen McGann uncover the facts behind allegations of foreign meddling in the 2016 presidential election. This groundbreaking exposé will leave readers questioning the motives of U.S. Intelligence agencies, leftover partisans within our government, and members of the mainstream press. Donald Trump's first 100 days in office were roiled by allegations of treasonous contacts between his campaign team and the Kremlin to rig the election. These outrageous charges first surfaced in the notorious “Trump Dossier,” an unverified document of suspect provenance, full of wild and salacious accusations. This dossier—filled with little more than gossip, rumor, and innuendo––was compiled by Christopher Steele, a former British intelligence operative who teamed up with the FBI and anti-Trump partisans. Hillary Clinton supporters paid for Steele’s work. When no news media would publish the unverified dossier, the ex-spook enlisted the help of a former UK ambassador to Russia, who arranged in turn for a former U.S. Assistant Secretary of State to get the document to Senator John McCain, in the hope that he would then bring it to FBI Director James Comey’s attention. McCain did just that. Comey himself played a critical role in the dossier ultimately going public, giving a confidential summary to President Obama and Congressional leaders. It was immediately leaked by rogue spooks in order to demean, destabilize, and destroy Donald Trump’s nascent presidency. The dossier and this mythical intelligence are the basis for the phony claims about a Russia/Trump collusion to steal the election. No proof was found. No substantiation uncovered. Even Comey told Trump he was not under investigation for the Russian meddling charges. But that didn’t end the leaks or the allegations. Working in concert with liberal news outlets, these rogue spooks have formed a new intel/media complex that threatens our democracy. Rogue Spooks will reveal how it works. Readers will be shocked to learn the truth about the false accusations against President Trump in the flawed dossier. They’ll be interested to know how leaks to the media fueled the phony scandal, and how intelligence agencies will try to use the newly appointed special prosecutor to oust President Trump. They will also learn what we can do—specifically—to stop them.

Biofunctional Surface Engineering

Author: Martin Scholz
Publisher: CRC Press
ISBN: 9789814411608
Release Date: 2014-02-21
Genre: Medical

Successful biofunctional surface engineering will determine the future of medical devices such as orthopedic implants, stents, catheters, vaccine scaffolds, wound dressings, and extracorporeal circulation devices. Moreover, the biosensor and diagnostic chip technology will evolve rapidly due to the growing medical need for personalized medicine. A major drawback in these technologies is the need for terminally sterilized products. However, novel and safe technologies, including coupling, stabilization, and protection of effector molecules, enable terminal sterilization without functional loss. This book provides a comprehensive overview on the state of the art and the future of biofunctional surface engineering and is of major interest for those working in the fields of medicine and medical devices.

Citizen Kill

Author: Stephen Clark
Publisher:
ISBN: 1937178854
Release Date: 2017-05-26
Genre: Fiction

When a devastating explosion kills the new President's young son, her administration seeks to finally end the war on terror. CIA black-ops agent Justin Raines is among the recruits in a new program that targets for assassination U.S. citizens suspected of radicalizing Muslims. Haunted by a botched assignment overseas, Justin is determined to redeem himself through the program. But when he is assigned to kill a mysterious Muslim educator that he believes is innocent, he grows disillusioned. Now he must find a way to prove her innocence and derail the program before they both are assassinated. This explosive political thriller will keep you on the edge of your seat as Washington stops at nothing to protect the nation from terrorists, while Justin Raines risks everything to protect the nation from Washington.

Keep Calm at Christmas

Author: Ebury Publishing
Publisher: Random House
ISBN: 9781448116317
Release Date: 2011-10-06
Genre:

Everyone knows 'tis the season to be jolly; when you can roast chestnuts on an open fire, treetops glisten and sleigh bells ring alongside the sound of small children's laughter. However, if you don't think Christmas is the most wonderful time of the year then reach for Keep Calm at Christmas and let its soothing advice reassure you that Christmas comes but once a year. Keep Calm at Christmas follows Keep Calm for Ladies and Keep Calm for Chaps and offers many merry pearls of wisdom to help you get through the festive season; on everything from relatives to office parties, and gluttony to new year resolutions. An insighftul pocket gift for Christmas. 'What I don't like about office Christmas parties is looking for a job the next day' Phyllis Diller 'About all you can do is dream of a white Christmas, for it seems like it always leaves most of us in the red' Anon 'Once again, we come to the Holiday Season, a deeply religious time that each of us observes, in his own way, by going to the mall of his choice' Anon 'Next to a circus there ain't nothing that packs up and tears out faster than the Christmas spirit' Kin Hubbard 'New Year's Day... now is the accepted time to make your regular annual good resolutions. Next week you can begin paving hell with them as usual' Mark Twain

Skin Bioscience

Author: Toyoko Imae
Publisher: CRC Press
ISBN: 9789814364959
Release Date: 2014-02-07
Genre: Medical

Skin bioscience is a core part of dermatology and brings important guiding principles to skin care and dermatological therapy. Although the investigation of human skin bioscience is not necessarily easy because of the limitations on the use of native human skin, many academic scientists and industrial engineers have been involved in this labored research with their creative ingenuity. In Skin Bioscience: A Molecular Approach, skin bioscience is introduced with a specific focus on the molecular approach. Following the description of the fundamental structure and unique functionality of the skin, the response of the skin to exterior stimulation is described. Furthermore, attention is paid to the beautification and regeneration of the skin. This book provides readers with the molecular knowledge of the skin and stimulates their interest in further investigation and development of skin bioscience.

Digital Electronics

Author: William Kleitz
Publisher: Prentice Hall
ISBN: 0132543036
Release Date: 2011-07
Genre: Technology & Engineering

Digital Electronics: A Practical Approach with VHDL, Ninth Edition, offers students an easy-to-learn-from resource that emphasizes practical application of circuit design, operation, and troubleshooting. Over 1,000 annotated color figures help explain circuit operation or emphasize critical components and input/output criteria. Throughout the text, the author employs a step-by-step approach that takes students from theory to example to application of the concepts. Over all nine editions, Kleitz has consistently sought out student feedback, along with his own experience of teaching the course in-class and on-line, to improve each new edition.

Risen Indeed

Author:
Publisher:
ISBN: 5550055600
Release Date: 2001-01-31
Genre:

An eloquent, thoughtful text is interwoven with and set to equally passionate music in this exploration of the most important week in the Christian calendar-Holy Week and Easter. As the "hosannas fade in crucify", we are led to wonder what we might have done, what we might have said, had we been there. What would our reaction have been to the shadow of the cross or the shock of the empty tomb? It is good to wonder, but it is better to know that because of the events of Holy Week, life eternal is the promise. For that, Christ paid the ultimate price, so that on Easter Sunday, all Christians can respond to the traditional Easter greeting, "The Lord Is Risen", with the affirmative response, "He is Risen Indeed!" From the quiet moments of introspection at the Lord's table to the terrible agony of the cross, and culminating with the joyous resurrection, this cantata is a moderately easy, yet completely satisfying and inspirational implement for worship. Indeed, He Is Risen!

Structural Steelwork Design to BS 5950

Author: L. J. Morris
Publisher: Trans-Atlantic Publications
ISBN: 0582230888
Release Date: 1996
Genre: Building, Iron and steel

This student text deals with design at an elementary level, familiarising the reader with BS 5950, then proceeds to cover all aspects of the design of whole buildings, highlighting the integration of elements to produce economic, safe structures.

Jerry West

Author: Roland Lazenby
Publisher: ESPN
ISBN: 9780345519269
Release Date: 2010-02-23
Genre: Biography & Autobiography

When in 1969 the NBA sought an emblem for the league, one man was chosen above all as the icon of his sport: Jerry West. Silhouetted in white against a red-and-blue backdrop, West’s signature gait and left-handed dribble are still the NBA logo, seen on merchandise around the world. In this marvelous book—the first biography of the basketball legend—award-winning reporter and author Roland Lazenby traces Jerry West’s brilliant career from the coalfields near Cabin Creek, West Virginia, to the bare-knuckled pre-expansion era of the NBA, from the Lakers’ Riley-Magic-Kareem Showtime era to Jackson–Kobe–Shaq teams of the early twenty-first century, and beyond. But fame was not all glory. Called “Mr. Clutch,” West was an incomparable talent—flawless on defense, possessing unmatched court vision, and the perfect jumper, unstoppable when the game was on the line. Beloved and respected by fans and fellow players alike, West was the centerpiece of Lakers teams that starred such players as Elgin Baylor and Wilt Chamberlain, and he went on to nine NBA Finals. Yet in losing eight of those series, including six in a row to the detested Boston Celtics, West became as famous for his failures as for his triumphs. And that notoriety cast long shadows over West’s life on and off the court. Yet as the author discovered through scores of exclusive interviews with West’s teammates, colleagues, and family members, West channeled the frustration of his darkest moments into a driving force that propelled his years as an executive. And in this capacity, the success that often eluded West on the court has enabled him to reach out to successive generations of players to enrich and shape the sport in immeasurable ways. Though sometimes overshadowed by flashier peers on the court, Jerry West nevertheless stands out as the heart and soul of a league that, in fifty years, has metamorphosed from a regional sideshow into a global phenomenon. And in Jerry West, Roland Lazenby provides the ultimate story of a man who has done more to shape basketball than anyone on the planet. From the Hardcover edition.