Biosensors Based on Aptamers and Enzymes

Author: Man Bock Gu
Publisher: Springer
ISBN: 9783642541438
Release Date: 2014-07-08
Genre: Technology & Engineering

Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Advances in Unconventional Computing

Author: Andrew Adamatzky
Publisher: Springer
ISBN: 9783319339214
Release Date: 2016-07-26
Genre: Computers

The unconventional computing is a niche for interdisciplinary science, cross-bred of computer science, physics, mathematics, chemistry, electronic engineering, biology, material science and nanotechnology. The aims of this book are to uncover and exploit principles and mechanisms of information processing in and functional properties of physical, chemical and living systems to develop efficient algorithms, design optimal architectures and manufacture working prototypes of future and emergent computing devices. This second volume presents experimental laboratory prototypes and applied computing implementations. Emergent molecular computing is presented by enzymatic logical gates and circuits, and DNA nano-devices. Reaction-diffusion chemical computing is exemplified by logical circuits in Belousov-Zhabotinsky medium and geometrical computation in precipitating chemical reactions. Logical circuits realised with solitons and impulses in polymer chains show advances in collision-based computing. Photo-chemical and memristive devices give us a glimpse on hot topics of a novel hardware. Practical computing is represented by algorithms of collective and immune-computing and nature-inspired optimisation. Living computing devices are implemented in real and simulated cells, regenerating organisms, plant roots and slime mould. The book is the encyclopedia, the first ever complete authoritative account, of the theoretical and experimental findings in the unconventional computing written by the world leaders in the field. All chapters are self-contains, no specialist background is required to appreciate ideas, findings, constructs and designs presented. This treatise in unconventional computing appeals to readers from all walks of life, from high-school pupils to university professors, from mathematicians, computers scientists and engineers to chemists and biologists.

Electrochemically Engineered Nanoporous Materials

Author: Dusan Losic
Publisher: Springer
ISBN: 9783319203461
Release Date: 2015-07-18
Genre: Technology & Engineering

This book provides in-depth knowledge about the fabrications, structures, properties and applications of three outstanding electrochemically engineered nanoporous materials including porous silicon, nanoporous alumina and nanotubular titania. The book integrates three major themes describing these materials. The first theme is on porous silicon reviewing the methods for preparation by electrochemical etching, properties and methods for surface functionalization relevant for biosensing applications. Biomedical applications of porous silicon are major focus, described in several chapters reviewing recent developments on bioanalysis, emerging capture probes and drug delivery. The second theme on nanoporous alumina starts with describing the concept of self-organized electrochemical process used for synthesis nanopore and nanotube structures of valve metal oxides and reviewing recent development and progress on this field. The following chapters are focused mainly on optical properties and biosensing application of nanoporous alumina providing the reader with the depth of understanding of the structure controlled optical and photonic properties and design of optical biosensing devices using different detection principles such as photoluminescence, surface plasmon resonance, reflective spectrometry, wave guiding, Raman scattering etc. The third theme is focused on nanotubular titania reviewing three key applications including photocatalysis, solar cells and drug delivery. The book represents an important resource for academics, researchers, industry professionals, post-graduate and high-level undergraduate students providing them with both an overview of the current state-of-the-art on these materials and their future developments.


Author: Friedrich Lottspeich
Publisher: John Wiley & Sons
ISBN: 9783527694464
Release Date: 2018-03-08
Genre: Science

Analytical methods are the essential enabling tools of the modern biosciences. This book presents a comprehensive introduction into these analytical methods, including their physical and chemical backgrounds, as well as a discussion of the strengths and weakness of each method. It covers all major techniques for the determination and experimental analysis of biological macromolecules, including proteins, carbohydrates, lipids and nucleic acids. The presentation includes frequent cross-references in order to highlight the many connections between different techniques. The book provides a bird's eye view of the entire subject and enables the reader to select the most appropriate method for any given bioanalytical challenge. This makes the book a handy resource for students and researchers in setting up and evaluating experimental research. The depth of the analysis and the comprehensive nature of the coverage mean that there is also a great deal of new material, even for experienced experimentalists. The following techniques are covered in detail: - Purification and determination of proteins - Measuring enzymatic activity - Microcalorimetry - Immunoassays, affinity chromatography and other immunological methods - Cross-linking, cleavage, and chemical modification of proteins - Light microscopy, electron microscopy and atomic force microscopy - Chromatographic and electrophoretic techniques - Protein sequence and composition analysis - Mass spectrometry methods - Measuring protein-protein interactions - Biosensors - NMR and EPR of biomolecules - Electron microscopy and X-ray structure analysis - Carbohydrate and lipid analysis - Analysis of posttranslational modifications - Isolation and determination of nucleic acids - DNA hybridization techniques - Polymerase chain reaction techniques - Protein sequence and composition analysis - DNA sequence and epigenetic modification analysis - Analysis of protein-nucleic acid interactions - Analysis of sequence data - Proteomics, metabolomics, peptidomics and toponomics - Chemical biology

Biosensors Based on Sandwich Assays

Author: Fan Xia
Publisher: Springer
ISBN: 9789811078354
Release Date: 2018-01-09
Genre: Science

This book shows the various sandwich assays that are constructed from recognition molecules, such as antibodies, oligonucleotide sequences and aptamers, developed as a result of nano- and biotechnology advances. It consists of ten chapters presenting interesting examples of these assays, organized according to the type of analytic methods (colorimetric, fluorescence, electrochemical, etc.) and detected objects (protein, nucleic acid, small-molecule, ion, etc.). It also includes a chapter discussing the introduction of sandwich assays as biosensors for the detection of a range of targets. It is an interesting and useful resource for a wide readership in various fields of chemical science and nanotechnology.


Author: Itamar Willner
Publisher: John Wiley & Sons
ISBN: 9783527604180
Release Date: 2006-03-06
Genre: Science

Medicine, chemistry, physics and engineering stand poised to benefit within the next few years from the ingenuity of complex biological structures invented and perfected by nature over millions of years. This book provides both researchers and engineers as well as students of all the natural sciences a vivid insight into the world of bioelectronics and nature's own nanotechnological treasure chamber.

The Nanobiotechnology Handbook

Author: Yubing Xie
Publisher: CRC Press
ISBN: 9781439838693
Release Date: 2012-11-16
Genre: Medical

A thorough overview of nanobiotechnology and its place in advances in applied science and engineering, The Nanobiotechnology Handbook combines contributions from physics, bioorganic and bioinorganic chemistry, molecular and cellular biology, materials science, and medicine as well as from mechanical, electrical, chemical, and biomedical engineering to address the full scope of current and future developments. World-class experts discuss the role of nanobiotechnology in bioanalysis, biomolecular and biomedical nanotechnology, biosensors, biocatalysis and biofuel, and education and workforce development. It includes a companion CD that contains all figures in the book. The book begins with discussions of biomimetic nanotechnology, including a comprehensive overview of DNA nanostructure and DNA-inspired nanotechnology, aptamer-functionalized nanomaterials as artificial antibodies, artificial enzymes, molecular motors, and RNA structures and RNA-inspired nanotechnology. It shows how nanotechnology can be inspired by nature as well as adverse biological events in diagnostic and therapeutic development. From there, the chapters cover major important and widely used nanofabrication techniques, applications of nanotechnology for bioprocessing followed by coverage of the applications of atomic force microscopy (AFM), optical tweezers and nanofluidics as well as other nanotechnology-enabled biomolecular and cellular manipulation and detection. Focusing on major research trends, the book highlights the importance of nanobiotechnology to a range of medical applications such as stem cell technology and tissue engineering, drug development and delivery, imaging, diagnostics, and therapeutics. And with coverage of topics such as nanotoxicity, responsible nanotechnology, and educational and workforce development, it provides a unique overview and perspective of nanobiotechnology impacts from a researcher’s, entrepreneur’s, economist’s and educator’s point of view. It provides a resource for current applications and future development of nanobiotechnology.

Biotechnologie f r Einsteiger

Author: Reinhard Renneberg
Publisher: Spektrum Akademischer Verlag
ISBN: 382741847X
Release Date: 2007

”Das Buch lAsst mich wA1/4nschen, ich wAre wieder ein Student. "Frederick Sanger, NobelpreistrAger 1958 und 1980" Die Zeit der Biotechnologie ist gekommen: Sie greift zunehmend in unser tAgliches Leben ein -- und dennoch fehlt neben Laien auch Studenten und Wissenschaftlern oft ein fundiertes Wissen. Abhilfe und eine FA1/4lle von Informationen bietet das einfA1/4hrende Lehrbuch von Reinhard Renneberg: eine verstAndlich geschriebene und visuell opulent aufbereitete Gesamtschau der Biotechnologie. Sie eignet sich zum SchmAkern ebenso wie fA1/4r ein intensives Studium und lAsst sich auch zum schnellen Nachschlagen benutzen. Aufgrund seines A1/4berwAltigenden Erfolgs liegt das Buch nun nach nunmehr knapp einem Jahr als aktualisierte und korrigierte Neuauflage vor. Wie Renneberg zeigt, kann ein wissenschaftliches Lehrbuch durchaus spannend und unterhaltsam geschrieben sein. Verschiedene didaktische Elemente ergAnzen den Grundtext: -Boxen zu speziellen Themen vertiefen das Wissen speziellen Themen und zur Geschichte -Meinungen von Experten veranschaulichen Standpunkte aus Forschung und Industrie -Doppelseiten mit Fotos zeigen wichtige Biotechnologie-Produkte und Prozesse sowie daran beteiligte Wissenschaftler -Panoramatafeln fassen das Wissen zusammen -alle wichtigen MolekA1/4le sind dreidimensional dargestellt - Cartoons von Manfred Bofinger und Chow Ming -acht Fragen am Ende jedes Kapitels erlauben eine Selbstkontrolle -Weblinks fA1/4hren zu ausgewAhlten Internet-Seiten Wissenschaft kann SpaA machen - das vermittelt dieses Buch schon beim DurchblAttern! Reinhard Renneberg ist seit 1995 Professor fA1/4r Analytische Biotechnologie an der Hong Kong University of Science and Technology ( Er ist Autor von drei Biotechnologie-SachbA1/4chern, Mitautor des Roempp-Biotechnologie-Lexikons, Verfasser von vier Monografien und 250 Publikationen und Urheber von 20 Patenten. DarA1/4ber hinaus ist er an zwei Biotechnologie-Firmen in Deutschland und China beteiligt. Darja SA1/4Abier ist wissenschaftliche Zeichnerin und hat bereits zahlreiche BA1/4cher illustriert. Mit ihrem ansprechenden, durchgehend vierfarbig gestalteten Layout und einer Vielzahl neu gezeichneter Grafiken hat sie diesem Lehrbuch eine ganz besondere Note verliehen. Stimmen zu diesem Buch: ”Hochaktuell und spannend wie ein Roman. Empfehle ich meinen Student(inn)en -- aber nicht als BettlektA1/4re, sonst verschlafen sie womAglich die Vorlesung.Prof. Dr. Peter Fischer, Technische Fachhochschule Berlin" ”Ein optisch sehr gut gestaltetes Buch. Der leicht verstAndliche Text und die vielen selbsterklArenden Abbildungen werden Einsteiger anregen, ihre Kenntnisse auf diesem Gebiet zu vertiefen.Dr. Gert-Wilenad Kohring, UniversitAt des Saarlandes, SaarbrA1/4cken" ”So spannend und lebensnah wurde Biotechnologie noch nie vermittelt!Assist. Prof. Oliver Kayser, Rijksuniversiteit Groningen" ”Ein herrlich erfrischendes Lehrbuch, das begeistert und Lust auf mehr macht!PD Dr. Martin Bertau, Technische UniversitAt Dresden" ”Warum mag ich dieses Lehrbuch? Ich lehre Studenten in allen Semestern Biochemie seit A1/4ber 30 Jahren und habe erfahren, dass Lehren und Lernen eng verbunden sind mit Faszination, Neugier und Humor. Reinhard RennebergAs "Biotechnologie fA1/4r Einsteiger" ist ein ausgezeichnetes Beispiel fA1/4r ein Lehrbuch, das diese Anforderungen erfA1/4llt.Prof. Dr. Hans GA1/4nter Gassen in Biotechnology Journal" ”Wenn Sie an der Biotechnologie interessiert sind, sollten Sie den Kauf dieses schAnen und guten Buches ins Auge fassen. Die Investition lohnt sich. Vertrauen Sie nicht auf eine Ausleihe in einer Bibliothek, denn die Vormerkerliste wird lang sein.Reinhold Ellmer in Chemie in Labor & Biotechnik" ”Ein im deutschsprachigen Raum bislang einmaliges Projekt, das hoffentlich Nachahmung findet. Kein Zweifel so macht Lernen SpaA und auch Wissenschaftler werden sicher g

Technisch Chemisches Praktikum

Author: Wladimir Reschetilowski
Publisher: John Wiley & Sons
ISBN: 9783527663743
Release Date: 2012-05-21
Genre: Science

Zu einer modernen Chemieausbildung geh rt ein Praktikum in technischer Chemie - und ein modernes, an den Erfordernissen der chemischen Industrie orientiertes Praktikumsbuch. In vielen praxisrelevanten und rechnergest tzten Versuchen zu den Themenbereichen Mess- und Regelungstechnik, Verfahrenstechnik und Reaktionstechnik eignet sich der Student fundiertes Wissen auf dem Gebiet der technischen Chemie an, das er sp ter im Berufsleben dringend braucht, wenn chemische Prozesse optimiert oder neu konzipiert werden m ssen. Ausgehend von Grundkenntnissen der Thermodynamik von Phasengleichgewichten und der chemischen Kinetik werden die physikalisch-chemischen Grundlagen fur die Auslegung von Prozesseinheiten zur mechanischen und thermischen Stofftrennung sowie fur prinzipielle M glichkeiten der Reaktionsf hrung mit der dazugeh rigen Mess- und Regelungstechnik vermittelt. Grundlage der in diesem Buch beschriebenen Praktikumsversuche ist das "Lehrprofil Technische Chemie" vom DECHEMA-Unterrichtsausschuss fur Technische Chemie.

Future Trends in Biotechnology

Author: Jian-Jiang Zhong
Publisher: Springer
ISBN: 9783642365089
Release Date: 2014-07-08
Genre: Science

Systems Metabolic Engineering: The Creation of Microbial Cell Factories by Rational Metabolic Design and Evolution, by Chikara Furusawa, Takaaki Horinouchi, Takashi Hirasawa, Hiroshi Shimizu Impacts of Quorum Sensing on Microbial Metabolism and Human Health, by Yang-Chun Yong, Jian-Jiang Zhong CHO Glycosylation Mutants as Potential Host Cells to Produce Therapeutic Proteins with Enhanced Efficacy, by Peiqing Zhang, Kah Fai Chan, Ryan Haryadi, Muriel Bardor, Zhiwei Song Cell-Free Biosystems for Biomanufacturing, by Chun You, Y.-H. Percival Zhang Lipid Bilayer Membrane Arrays: Fabrication and Applications, by Xiaojun Han, Guodong Qi, Xingtao Xu, Lei Wang RNA Aptamers: A Review of Recent Trends and Applications, by Kyung-Nam Kang, Yoon-Sik Lee

Portable Biosensing of Food Toxicants and Environmental Pollutants

Author: Dimitrios P. Nikolelis
Publisher: CRC Press
ISBN: 9781466576339
Release Date: 2013-10-21
Genre: Science

Biosensors are poised to make a large impact in environmental, food, and biomedical applications, as they clearly offer advantages over standard analytical methods, including minimal sample preparation and handling, real-time detection, rapid detection of analytes, and the ability to be used by non-skilled personnel. Covering numerous applications of biosensors used in food and the environment, Portable Biosensing of Food Toxicants and Environmental Pollutants presents basic knowledge on biosensor technology at a postgraduate level and explores the latest advances in chemical sensor technology for researchers. By providing useful, state-of-the-art information on recent developments in biosensing devices, the book offers both newcomers and experts a roadmap to this technology. In the book, distinguished researchers from around the world show how portable and handheld nanosensors, such as dynamic DNA and protein arrays, enable rapid and accurate detection of environmental pollutants and pathogens. The book first introduces the basic principles of biosensing for newcomers to the technology. It then explains how the integration of a "receptor" can provide analytically useful information. It also describes trends in biosensing and examines how a small-sized device can have portability for the in situ determination of toxicants. The book concludes with several examples illustrating how to determine toxicants in food and environmental samples.

Proteomic and Genomic Analysis of Cardiovascular Disease

Author: Jennifer E. Van Eyk
Publisher: Wiley-Blackwell
ISBN: 3527305963
Release Date: 2003-04-10
Genre: Science

This is the very first book to focus on this new approach that will eventually aid in developing new diagnostic markers and therapies for controlling and treating heart disease - the number-one killer in the industrialized world. Divided into two parts, the book describes not only the potentials, but also the limitations of these technologies. The editors, both well known within the scientific community, provide new insights into the biochemical and cellular mechanisms of cardiovascular disease, as well as covering the transition into clinical applications. In so doing, they highlight the various strategies and technical aspects so as to assist the growing number of researchers intending to utilize these approaches. The result is an excellent way of educating and informing graduate students, post-doctoral fellows as well as researchers in academia and industry about the latest developments in this area.


Author: Jürgen Gmehling
Publisher: Wiley-VCH
ISBN: 3527308512
Release Date: 1996-06-13
Genre: Science

Anhand ausgewählter Beispiele werden dem Leser thermische und mechanische Grundoperationen dargelegt und schwerpunktmäßig folgende Themen behandelt: - Stoff-, Wärmetransport sowie Strömungslehre - Berechnung von Phasengleichgewichten (insbesondere zur übergeordneten Darstellung aller thermischen Trennverfahren) - Prinzipien und technische Anwendungen der thermischen Stofftrennung anhand der Rektifikation, der Absorption, der Flüssig-Flüssig-Extraktion sowie weiterer technisch bedeutsamer Trennverfahren (Fest-Flüssig-Extraktion, Extraktion mit überkritischen Gasen, Kristallisation, Adsorption und Membranverfahren) - Mechanische Grundoperationen, wie Rühren, Filtrieren, andere mechanische Misch- und Trennverfahren sowie die Behandlung von Feststoffen (vom Zerkleinern bis zur Formgebung von Katalysatoren) Besonders die im Text eingestreuten Rechenbeispiele helfen, den Lernstoff zu vertiefen. Ein abgedrucktes Computerprogramm erlaubt die Berechnung auch komplexerer Rektifikationsverfahren. Dieses ausführlich bearbeitete Lehrbuch eignet sich als berufsbegleitendes Nachschlagewerk und zur Auffrischung von Wissen hervorragend. Inhaltlich entspricht das Werk der vom DECHEMA Unterrichtsausschuss für Technische Chemie angegebenen Empfehlung.